The effect of d-fenfluramine on intake of carbohydrate supplements is influenced by the hydration of the test diets.

摘要: The effect of d-fenfluramine on carbohydrate intake in the rat has been investigated using a dietary paradigm which pure supplement is presented addition to normal balanced chow diet. This experimental strategy used as an alternative macronutrient selection model attempt increase sensitivity measurement drug effects intake. issue important because postulated theoretical relationship between brain serotonin (5-HT) and was dependent upon texture density (hydrated vs. non-hydrated) nature carbohyhdrate employed - either sucrose (sweet-tasting) or Polycose (bland-tasting). Selective suppression, by d-fenfluramine, detected (as predicted 5-HT/carbohydrate theory) but only under specific environmental conditions, namely hydrated supplemented with dry Polycose. Therefore, suppression may depend, not any inherent biological link consumption 5-HT activity, shift relative preference for diet choices available.