Celecoxib in patients with asthma and aspirin intolerance. The Celecoxib in Aspirin-Intolerant Asthma Study Group.
作者： Barbro Dahlén , Andrew Szczeklik , John J. Murray
DOI: 10.1056/NEJM200101113440215
关键词: Cyclooxygenase 、 Asthma 、 In patient 、 Bronchospasm 、 ASPIRIN INTOLERANCE 、 Medicine 、 Aspirin 、 Pharmacology 、 Arthritis 、 Celecoxib
摘要: To the Editor: In some patients with asthma, administration of aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) leads to bronchospasm.1 The reaction is related inhibition cyclooxygenase (COX) enzyme that catalyzes prostaglandin production. Two isoforms (COX-1 COX-2) have been identified, but it not known which isoform involved in intolerance NSAIDs. We examined 27 for bronchospasm after celecoxib,2 a selective COX-2 inhibitor recently introduced as an treatment arthritis asthma intolerance. (17 women 10 men . . .
sci-hub.se 参考文章(3)
Andrew Szczeklik, Donald D. Stevenson, Aspirin-induced asthma: advances in pathogenesis and management. The Journal of Allergy and Clinical Immunology. ,vol. 104, pp. 5- 13 ,(1999) , 10.1016/S0091-6749(99)70106-5
Delyth Clemett, Karen L. Goa, Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain. Drugs. ,vol. 59, pp. 957- 980 ,(2000) , 10.2165/00003495-200059040-00017
BARBRO DAHLÉN, EWA NIZANKOWSKA, ANDREW SZCZEKLIK, OLLE ZETTERSTRÖM, GRAZYNA BOCHENEK, MARIA KUMLIN, LUCYNA MASTALERZ, GRAZYNA PINIS, LINDA J. SWANSON, TERRY I. BOODHOO, STEPHEN WRIGHT, LOUISE M. DUBÉ, SVEN-ERIK DAHLÉN, Benefits from Adding the 5-Lipoxygenase Inhibitor Zileuton to Conventional Therapy in Aspirin-intolerant Asthmatics American Journal of Respiratory and Critical Care Medicine. ,vol. 157, pp. 1187- 1194 ,(1998) , 10.1164/AJRCCM.157.4.9707089