MODIFICATION OF CATECHOLAMINE RELEASE BY ANAESTHETICS AND ALCOHOLS

摘要: Publisher Summary This chapter discusses modification of the catecholamine release by anaesthetics and alcohols both in central nervous system periphery. The inhibition function neurons brain may be involved mechanism action anaesthetics. Studies concerning effects chronic ethanol administration withdrawal on noradrenaline turnover are consistent; acceleration appears to reflect an increase release. Catecholamine from adrenergic have clearly shown that acute decreases response various methods stimulation, whereas spontaneous output is increased. In peripheral neurons, inhalation inhibit evoked potassium chloride or activation nicotinic receptors nerve terminals. All intravenous investigated can cause stimulated release, at least when KCl acetylcholine used for stimulation. However, because pentobarbital inhibits electrically tissue only lethal concentrations, found vivo studies does not appear direct effect drug terminals but rather results a decreased rate impulse flow. Ethanol concentrations compatible with moderate intoxication equivalent those measured during clinical anaesthesia affect membrane neurons.