Synthetic retinoid CD437 induces mitochondria-mediated apoptosis in hepatocellular carcinoma cells.
作者： Kazue Gonda , Hiroyuki Tsuchiya , Tomohiko Sakabe , Yuji Akechi , Remina Ikeda
DOI: 10.1016/J.BBRC.2008.04.008
关键词: Downregulation and upregulation 、 Cell biology 、 Cancer research 、 Intrinsic apoptosis 、 Apoptosis 、 Biology 、 Cell growth 、 Signal transduction 、 Cytochrome c 、 Cell culture 、 Mitochondrion
摘要: Retinoids play an important role in the regulation of cell growth and death. Synthetic retinoid CD437 reportedly induces apoptosis various cancer lines. However, mechanism inducing hepatocellular carcinoma (HCC) cells by this agent remains to be clarified. In study, we investigated signaling pathway which HCC Apoptosis six human lines was induced treatment with CD437. Caspase-3 -9 were activated CD437, suggesting that is mediated mitochondrial pathways. Consistent these findings, upregulated Bax protein, downregulated Bcl-2 protein released cytochrome c into cytoplasm. Moreover, rhodamine123 staining revealed depolarization treated These data present study suggest via
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