Clinical Patterns of Failure After Resection of Colon and Rectum Carcinoma Metastases to the Liver

摘要: Data are presented on 43 patients from Brigham and Women’s Hospital who underwent major hepatic resections for cure of primary secondary liver tumors. These included 30 asymptomatic colorectal cancer with single or multiple resectable metastases. The results this series were analyzed by carefully documenting the clinical patterns failure surgical procedures. reinforce value serial elevation carcinoembryonic antigen as best indicator recurrence in predominantly patients. Not surprising based natural history disease is observation that majority unresected die whereas following resection, death outside liver. Thus, pattern after resection metastases suggests proximate cause these has been changed. Although data confirm safety performed properly selected patients, most important predictor local metastatic was lack clean margins at time initial resection. Hence, while due to involvement may be prevented surgically, initiation systemic adjuvant therapy protocols should our treatment goal. To accomplish objective, however, more effective large bowel must developed.