Solubility of chloroxine in aqueous co-solvent mixtures of N,N-dimethylformamide, dimethyl sulfoxide, N-methyl-2-pyrrolidone and 1,4-dioxane: Determination, solvent effect and preferential solvation analysis

摘要: Abstract The equilibrium solubility of amorphous chloroxine in four co-solvent mixtures dimethyl sulfoxide (DMSO) (1) + water (2), N , -dimethylformamide (DMF) -methyl-2-pyrrolidone (NMP) (2) and 1,4-dioxane is reported. Experiments were performed by using the saturation shake-flask technique over temperature range from (293.15 to 333.15) K. maximum was observed neat DMF (DMSO, NMP or 1,4-dioxane) for mixtures. By Jouyban-Acree model, well correlated obtaining RAD values lower than 3.64 % RMSD 8.82×10 -6 . Quantitative local mole fraction DMSO (DMF, around computed Inverse Kirkwood–Buff integrals method applied determined data. Chloroxine preferentially solvated studied water-rich compositions; while within intermediate co-solvent-rich compositions, Moreover, light Kamlet Taft linear solvation energy relationships co-solvency effect rationalized, relative importance solvent-solute solvent-solvent interactions recognized. It shown that change interaction accounted cavity term governed variation all aqueous