Short Communication Characterization of Prostate Cell Types by CD Cell Surface Molecules

摘要: A set of monoclonal antibodies raised against lymphocyte cell surface molecules, the cluster designation (CD) antigens, was used to distinguish constituent types prostate. The luminal secretory epithelial , basal fibromuscular stromal, nerve sheath, and endothelial cells express distinctive complements molecules that were identified by immunohistochemistry using 152 commercially available antibodies. Many CD stained populations in These grouped into abundance classes rare, moderate, high. Some these are expressed multiple types, both parenchymal lymphoid; others only one type. Distinctive patterns expression, which most similar expression pattern prostate cells, also characterize a small series Gleason score 6 cancers. cell-type specificity increases prospect isolating specific populations, such techniques as laser capture microdissection flow cytometry, for cell-specific molecular studies. (Am J Pathol 2002, 160:37–43)