Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles
作者： W. McKinney , M. Jackson , T. M. Sager , J. S. Reynolds , B. T. Chen
DOI: 10.3109/08958378.2012.685111
关键词: Anesthesia 、 Titanium dioxide 、 Phenylephrine 、 Specific Airway Resistance 、 Inhalation 、 Lung 、 Particle size 、 Chromatography 、 Respiratory rate 、 Titanium 、 Medicine
摘要: Our laboratory has previously demonstrated that application of an antimicrobial spray product containing titanium dioxide (TiO2) generates aerosol in the breathing zone applicator. The present report describes design automated system and characterization delivered to a whole body inhalation chamber. This produced stable airborne levels TiO2 particles with median count size diameter 110 nm. Rats were exposed 314 mg/m3 min (low dose), 826 (medium 3638 (high dose) under following conditions: 2.62 for 2 h, 1.72 4 h/day days, 3.79 respectively. Pulmonary (breathing rate, specific airway resistance, inflammation, lung damage) cardiovascular (the responsiveness tail artery constrictor or dilatory agents) endpoints monitored 24 h post-exposure. No significant pulmonary changes noted at low mid...
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