Chiral tertiary propargylic alcohols via Pd-catalyzed carboxylative kinetic resolution
作者： Jie Wang , Wanli Zhang , Penglin Wu , Chaofan Huang , Yangguangyan Zheng
DOI: 10.1039/D0QO01106A
关键词: Reaction conditions 、 Catalysis 、 Chemistry 、 Alcohol 、 Combinatorial chemistry 、 Kinetic resolution 、 Stereocenter
摘要: A highly efficient Pd/H+-cocatalyzed kinetic resolution reaction of tertiary propargylic alcohols has been reported. The method provides an approach to prepare a series bearing chiral quaternary stereocenter in good yields and remarkable enantioselectivities (93–>99% ee) under mild operationally simple conditions tolerating broad range functional groups. practicality this demonstrated via the 4-gram-scale synthesis alcohol (S)-1a.
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