Detection of secreted aspartyl proteases from Candida species

作者: Erica M. Phillips , Kevin P. McGrath , Enrico L. DiGiammarino

DOI:

关键词: MicrobiologyEpitopePolyclonal antibodiesHyphal growthAntibodyCorpus albicansMicroorganismBiologyMonoclonal antibodyDownregulation and upregulation

摘要: Methods and devices for the detection of proteins secreted by hyphal growth form Candida species are disclosed. The disclosed may constitute a method diagnosis acute or chronic infections, including candidiasis, caused microorganisms Candida, such as C. albicans, example. present invention incorporate antibodies specific to aspartyl protease whose expression is upregulated upon conversion from commensal pathogenic form. be used in assays allow candidal infections disease conditions. Either monoclonal polyclonal used, case monoclonals, epitopes SAP protein detected well itself.

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