Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

摘要: Currently available human tumour cell line panels consist of a small number lines in each lineage that generally fail to retain the phenotype original patient tumour. Here we develop culture medium enables us routinely establish from diverse subtypes ovarian cancers with >95% efficiency. Importantly, 25 new described here genomic landscape, histopathology and molecular features tumours. Furthermore, profile drug response these correlate distinct groups primary tumours different outcomes. Thus, derived using this methodology represent significantly improved platform study pathophysiology therapy.