KDO aldolase and condensation reactions employed therewith
作者： Chi-Huey Wong , Gwo-Jenn Shen , Takeshi Sugai
DOI:
关键词: Condensation reaction 、 Fructose-bisphosphate aldolase 、 Bacterial outer membrane 、 Strain (chemistry) 、 Stereochemistry 、 Aldolase A 、 Yield (chemistry) 、 Organic chemistry 、 Substrate specificity 、 Reversible reaction 、 Chemistry
摘要: Aureobacterium barkerei strain KDO-37-2 (ATCC 49977) KDO aldolase (EC 4.1.2.23) isolated therefrom are disclosed. The DKDO is further disclosed to have a broad substrate specificity with respect its reverse reaction, i.e. the condensation of aldoses pyruvate form wide range 2-keto-3-deoxy-onic acids, including 2-keto-3-deoxy-nonulosonic acid, 2-keto-3-deoxy-octulosonic 2-keto-3-deoxy-heptulosonic and 2-keto-3-deoxy-hexulosonic acid. In particular, 3-deoxy-D-manno-2-octulosonic acid (D-KDO), vital component lipopolysaccharides found in bacterial outer membrane may be synthesized from D-arabinose 67 % yield. Additionally, protected forms products, e.g. hexaacetyl pentaacetyl decarboxylated corresponding 2-deoxy-aldoses, 2-deoxy-octulose 2-deoxy-heptulose respectively.
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