A total synthesis of polyether antibiotic (−)-A23187 (calcimycin)
作者： David P Negri , Yoshito Kishi
DOI: 10.1016/S0040-4039(00)95911-2
关键词: Stereospecificity 、 Calcimycin 、 Total synthesis 、 Enantiomer 、 Chemistry 、 Bicyclic molecule 、 Acetal 、 Antibiotic A23187 、 Stereochemistry 、 Ketone
摘要: Abstract A total synthesis of (−)-A23187 (calcimycin) was accomplished by a convergent approach. The key step the stereospecific cyclization β-hydroxy ketone into spiroketal under basic conditions.
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