Beauvericin-induced cytotoxicity via ROS production and mitochondrial damage in Caco-2 cells.

作者: A. Prosperini , A. Juan-García , G. Font , M.J. Ruiz

DOI: 10.1016/J.TOXLET.2013.07.005

关键词: Programmed cell deathDNA damageGlutathioneCell biologyMolecular biologyCell growthApoptosisBeauvericinOxidative stressBiologyReactive oxygen species

摘要: … George (2004) by using the H 2 -DCFDA probe. DCFH-DA is taken up by the cells, then deacetylated by intracellular esterases and the resulting H 2 -DCFDA is oxidized by ROS to the …

参考文章(42)
John A. Buege, Steven D. Aust, Microsomal lipid peroxidation. Methods in Enzymology. ,vol. 52, pp. 302- 310 ,(1978) , 10.1016/S0076-6879(78)52032-6
Guillermo Repetto, Ana del Peso, Jorge L Zurita, Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nature Protocols. ,vol. 3, pp. 1125- 1131 ,(2008) , 10.1038/NPROT.2008.75
Maja Šegvić Klarić, Dina Daraboš, Ružica Rozgaj, Vilena Kašuba, Stjepan Pepeljnjak, Beauvericin and ochratoxin A genotoxicity evaluated using the alkaline comet assay: single and combined genotoxic action. Archives of Toxicology. ,vol. 84, pp. 641- 650 ,(2010) , 10.1007/S00204-010-0535-7
Yudai Gotoh, Takahiro Noda, Ryuichi Iwakiri, Kazuma Fujimoto, Carol A. Rhoads, Tak Yee Aw, Lipid peroxide-induced redox imbalance differentially mediates CaCo-2 cell proliferation and growth arrest. Cell Proliferation. ,vol. 35, pp. 221- 235 ,(2002) , 10.1046/J.1365-2184.2002.00241.X
Laura Marabini, Rossella Calò, Serena Fucile, Genotoxic effects of polychlorinated biphenyls (PCB 153, 138, 101, 118) in a fish cell line (RTG-2). Toxicology in Vitro. ,vol. 25, pp. 1045- 1052 ,(2011) , 10.1016/J.TIV.2011.04.004
Amel Chatti Gazzah, Emna El Golli Bennour, Chayma Bouaziz, Salwa Abid, Moncef Ladjimi, Hassen Bacha, Sequential events of apoptosis induced by zearalenone in cultured hepatocarcinoma cells Mycotoxin Research. ,vol. 26, pp. 187- 197 ,(2010) , 10.1007/S12550-010-0053-8
S Orrenius, Mitochondrial regulation of apoptotic cell death. Toxicology Letters. ,vol. 149, pp. 19- 23 ,(2003) , 10.1016/J.TOXLET.2003.12.017
K Kouri, M Lemmens, R Lemmens-Gruber, Beauvericin-induced channels in ventricular myocytes and liposomes. Biochimica et Biophysica Acta. ,vol. 1609, pp. 203- 210 ,(2003) , 10.1016/S0005-2736(02)00689-2
Maja Šegvić Klarić, Lada Rumora, Danica Ljubanović, Stjepan Pepeljnjak, Cytotoxicity and apoptosis induced by fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment Archives of Toxicology. ,vol. 82, pp. 247- 255 ,(2008) , 10.1007/S00204-007-0245-Y