Solution Structures of Hauser Base iPr2NMgCl and Turbo-Hauser Base iPr2NMgCl·LiCl in THF and the Influence of LiCl on the Schlenk-Equilibrium
作者： Roman Neufeld , Thorsten L. Teuteberg , Regine Herbst-Irmer , Ricardo A. Mata , Dietmar Stalke
DOI: 10.1021/JACS.6B00345
关键词: Diffusion 、 Schlenk equilibrium 、 Hauser base 、 Organic chemistry 、 Halide 、 Computational chemistry 、 Chemical synthesis 、 Base (chemistry) 、 Reagent 、 Substituent 、 Chemistry
摘要: Grignard reagents that are at the simplest level described as “RMgX” (where R is an organic substituent and X a halide) one of most widely utilized classes synthetic reagents. Lately, especially with amido ligands type R1R2NMgX, so-called Hauser bases, their Turbo analogue R1R2NMgX·LiCl play outranging role in modern chemistry. However, because complex solution behavior, where Schlenk-type equilibria involved, very little known about structure solution. Especially impact LiCl on Schlenk-equilibrium was still obscured by complexity limited analytical access. Herein, we present unprecedented insights into base iPr2NMgCl 1 Turbo-Hauser iPr2NMgCl·LiCl 2 various temperatures THF-d8 employing newly elaborated diffusion ordered spectroscopy (DOSY) NMR method hand-in-hand theoretical calculations.
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