Sex-dimorphic role of prefrontal oxytocin receptors in social-induced facilitation of extinction in juvenile rats.

摘要: We previously reported that in the adult animal extinction pairs resulted enhanced extinction, showing social presence can reduce acquired fear responses. Based on our findings juvenile and animals differ mechanisms of here we address whether a conspecific affects similarly to adults. further such has different impact males females. To end, examined established experimental setting conditioned male female extinguish contextual memory better while pairs. Taking advantage role oxytocin (OT) mediation interaction, also study effect antagonizing OT receptors (OTR) either systemically or prefrontal cortex interaction-induced effects extinction. The results show accelerates females as compared single condition. Yet, differential opposing an OTR antagonist both sexes. Whereas females, systemic application is associated with impaired it males. In contrast, not engaged males, critical Previously differences levels between might explain action. These suggest even during period, are differently involved regulation