Nucleic acids encoding a novel influenza virus non-structural protein (NS1)-binding host factor designated NS1I-1
作者： Peter Palese , Robert O'Neill
DOI:
关键词: Viral transformation 、 Virus 、 Viral envelope 、 Viral structural protein 、 Biology 、 Host factor 、 Virology 、 Viral entry 、 Viral matrix protein 、 Viral replication
摘要: The present invention relates to the identification of host cell proteins that interact with viral required for virus replication, and high throughput assays identify compounds interfere specific interaction between protein. Interfering inhibit replication can be used therapeutically treat infection. is based, in part, on Applicants' discovery novel interactions influenza a human proteins. One these proteins, referred herein as NPI-1, interacts protein NP, may an accessory virus. Another NS1I-1, NS 1 . Compounds binding useful treating infection vivo.
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