Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease

作者: Brian Kaspar , Arthur Burghes , Paul Porensky

DOI:

关键词: Molecular biologyMedicineNon ionicAntisense oligonucleotides

摘要: Disclosed are compositions comprising an antisense oligonucleotide and a non-ionic, low-osmolar contrast agent. Also disclosed methods of delivering to target sire incorporating the into composition treating neurodegenerative disease administering one or more herein.

参考文章(128)
Lawrence V. Hofmann, Luke J. Higgins, Gloria L. Hwang, Nonviral gene delivery vector iopamidol, protamine, ethiodized oil reagent (viper) ,(2011)
Muthunadar P. Periasamy, Brian D. Doty, Low osmolar x-ray contrast media formulations ,(2005)
Hsiu Mei Hsieh-Li, Jan-Gowth Chang, Yuh-Jyh Jong, Mei-Hsiang Wu, Nancy M. Wang, Chang Hai Tsai, Hung Li, A mouse model for spinal muscular atrophy Nature Genetics. ,vol. 24, pp. 66- 70 ,(2000) , 10.1038/71709
Tohru Yamada, Chang Soo Hong, Arsenio M. Fialho, Tapas K. Das Gupta, Ananda M. Chakrabarty, Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof ,(2006)
David R. Elmaleh, John W. Babich, Alan J. Fischman, Targeted nucleic acid constructs and uses related thereto ,(2002)
Anil Sood, Eylem Ozturk, Angela Sanguino, Emir Baki Denkbas, Gabriel Lopez-Berestein, Methods and compositions involving chitosan nanoparticles ,(2008)
David J. Yang, Ali Azhdarinia, Chang Sok Oh, Saady Kohanim, Dong-Fang Yu, Compositions and methods for cellular imaging and therapy ,(2006)
Analia Alejandra Bortolozzi Biassoni, Andrés Pablo Montefeltro, Miquel Vila Bover, Francesc Artigas Perez, Gabriel Alvarado Urbina, Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types ,(2011)
Changsok Oh, Mithu Chanda, David J. Yang, Ali Azhdarinia, E. Edmund Kim, Dongfang Yu, Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications ,(2006)
Adrian R. Krainer, Brenda F. Baker, Yimin Hua, Compositions and methods for modulation of smn2 splicing ,(2006)