Drug and protein delivery by polymer conjugation

摘要: Abstract Drug and protein delivery techniques methods, which, in most cases, are concurrently investigated from the very time a new molecular entity is proposed, have become valuable tools for development of numerous therapeutic molecules. Attracting attention academia industrial researchers, several polymer conjugation methodologies been shown to wide range applications success rate that confirmed by conjugates already clinical use or under investigation on-going trials. Having attained high level sophistication, this technology able generate homogeneous exploiting specifically designed coupling strategies (based, example, on enzymes), which ensure good product characterization, activity retention, batch-to-batch reproducibility. Poly(ethylene glycol) (PEG), current gold standard stealth polymers emerging field polymer-based drug delivery, competition with other convenient features such as biodegradability. PEG still holds first place far PEGylated derivatives trials concerned, it will presumably remain choice even future further improvements copolymers based overcome example hurdle