Effects of the Ketogenic Diet on Acute Seizure Models

摘要: The ketogenic diet (KD) is both a therapy and tool for investigating the mechanisms of seizures and, perhaps, epilepsy. Despite our ignorance by which KD acts to alter seizures, observation that seizure threshold can vary widely depending on what an animal eats suggests (patho)physiological variable. general hypothesis underlying experimental studies that, understanding physiological changes consequent switch from carbohydrate-based metabolism one based fats, we might gain insight into fundamental processes affect ictogenesis. If person whose are controlled abandons abruptly suffers seizure, then consider elevated blood glucose (or decreased ketonemia) be ictogenic. Because central nervous system (CNS) normally entirely glucose, success KDs in treating epilepsies presents interesting questions opportunities.