Latent membrane protein 1 encoded by Epstein-Barr virus modulates directly and synchronously cyclin D1 and p16 by newly forming a c-Jun/Jun B heterodimer in nasopharyngeal carcinoma cell line.
作者： X. Song , Y.G. Tao , L. Zeng , X.Y. Deng , L.M. Lee
DOI: 10.1016/J.VIRUSRES.2005.04.019
关键词: Epstein–Barr virus 、 Cell cycle 、 c-jun 、 Cyclin A 、 Cyclin D 、 Biology 、 Cell biology 、 Cyclin A2 、 Cancer research 、 Cyclin D1 、 Transcription factor
摘要: Recently we confirmed that latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV) accelerates a newly forming active c-Jun/Jun B heterodimer, transcription factor, but little is known about the target gene regulated it. In this paper, results indicated heterodimer induced LMP1 upregulated cyclin D1 promoters activity and expression, on contrary, downregulated p16, maladjustment of p16 expression accelerated progression cell cycle. Firstly, found synchronously directly in Tet-on-LMP1-HNE2 line, which Tet-on system. This paper investigated depth function built new connection between environmental pathogenic signal transduction
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