The Role of the Proteasome in Platelet Function

摘要: Platelets are megakaryocyte-derived acellular fragments prepped to maintain primary hemostasis and thrombosis by preserving vascular integrity. Although they lack nuclei, platelets harbor functional genomic mediators that bolster platelet activity in a signal-specific manner performing limited de novo protein synthesis. Furthermore, despite their synthesis, equipped with multiple degradation mechanisms, such as the proteasome. In nucleated cells, functions of proteasome well established primarily include proteostasis among myriad other signaling processes. However, role proteasome-mediated remains elusive. this review article, we recapitulate developing literature on platelets, discussing its emerging regulatory viability function highlighting how coupling transcription factor NF-κB constitutes novel potential therapeutic target atherothrombotic diseases.