Dorsally derived spinal interneurons in locomotor circuits.

摘要: During neuronal circuit formation, axons are guided to their targets by the help of axon guidance molecules, which required for establishing functional circuits. A promising system dissect development and functionalities circuitry is spinal cord central pattern generator (CPG) locomotion, converts a tonic supraspinal drive rhythmic coordinated movements. Here we describe concepts arising from genetic studies locomotor network with focus on position roles commissural interneurons. In particular, this involves several families molecules relevant midline crossing, Eph/ephrins Netrin/DCC. Effects developing interneurons in mice aberrant capabilities suggest that, addition ventral populations, dorsal also play role coordinating circuitry. Recent findings implicate novel dI6 interneuron marker Dmrt3 role. Strikingly, mutations result divergent gait patterns both horses.