作者: Colin M.L. Burnett , Justin L. Grobe
DOI: 10.1016/J.MOLMET.2014.03.003
关键词: Internal medicine 、 Metabolism 、 Bioinformatics 、 Metabolic rate 、 Direct calorimetry 、 Basal metabolic rate 、 Respirometry 、 Endocrinology 、 Biology 、 High fat diet 、 C57BL/6
摘要: Abstract Resting metabolic rate (RMR) studies frequently involve genetically-manipulated mice and high fat diets (HFD). We hypothesize that the use of inadequate methods impedes identification novel regulators RMR. This idea was tested by simultaneously measuring RMR direct calorimetry respirometry in C57BL/6J fed chow, 45% HFD, then returned to chow. Comparing results during chow feeding uncovered an underestimation (0.010 ± 0.001 kcal/h, P