Years of sorafenib investigation in advanced non-small cell lung cancer: is there a 'NExUS' linking an unsuccessful treatment and a potentially active one?
作者： Giulio Metro , Lucio Crinò , Vincenzo Minotti
DOI: 10.3978/J.ISSN.2072-1439.2012.10.06
关键词: Medicine 、 Sorafenib 、 Clinical research 、 Growth factor 、 Lung cancer 、 Bioinformatics 、 Non small cell 、 Receptor 、 Cancer research 、 Vascular endothelial growth factor
摘要: Sorafenib, a multi-targeted receptor tyrosine-kinase inhibitor (TKI) with supposedly predominant anti-angiogenic activity (inhibition of vascular endothelial growth factor receptor-2, -3 and platelet-derived s), has been the subject extensive clinical research in advanced non-small cell lung cancer (NSCLC).
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