Assessment of ECG interval and restitution parameters in the canine model of short QT syndrome

摘要: Abstract Introduction The short QT syndrome (SQTS) is characterized by a interval resulting from accelerated ventricular repolarization, and may be associated with fibrillation but not torsades de pointes. There are abundant data on the adverse effects of long QT, knowledge SQTS sparse. aim this study was to examine whether analyses several ECG biomarkers (QT, QTcB, QTcF, QTcV, QTbtb, QTRR1000) dynamic restitution beat-to-beat QT–TQ relationship (TQmin, %QT/TQ ratio > 1, QT/TQ ratiomax) can used assess changes in conscious dogs. Methods Sling-trained dogs were infused escalating concentration levcromakalim (0, 1.0, 3.3, 10.0 µg/kg/min), pinacidil 10.0, 33.3 µg/kg/min), nicorandil 0.03, 0.1, 0.3 mg/kg/min), drugs known shorten QT. RR, QTRR1000, TQ measured before after each shortening test compounds. Results Levcromakalim, pinacidil, vehicle significantly shortened QTc(B,F,V). QT–RR cloud also shifted lower bounds normal boundary percentage beats ratio > 1 increased dose response manner (5th percentile) decreased when compared baseline or vehicle. Discussion measurements constitute clinically applicable for assessment arrhythmogenic risk due abbreviation.