Egg white coated alginate nanoparticles with electron sprayer for potential anticancer application
作者： Jianhua Zhang , Jun Huang , Keqing Huang , Jiayuan Zhang , Zhengqiu Li
DOI: 10.1016/J.IJPHARM.2019.04.045
关键词: Nanoparticle 、 High-performance liquid chromatography 、 Particle size 、 Nuclear chemistry 、 Egg white 、 Staining 、 Transmission electron microscopy 、 Biocompatibility 、 Paclitaxel 、 Chemistry
摘要: To development biomimetic strategy for enhanced cancer therapy, the paclitaxel loaded egg white/sodium alginate nanoparticles were prepared by electronic spray method. Their appearance and particle size observed transmission electron microscope analyzer. The drug release behavior of was determined high performance liquid chromatography (HPLC). toxicity, morphology interaction to cells studied means MTT, live/dead staining laser scanning confocal microscopy. results show that have good dispersion, regular morphology, performance, biocompatibility in vitro effective inhibition CT26 colorectal cells. These demonstrated white coated sodium PTX these would potential application therapy.
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