Effect of highly purified eicosapentaenoic acid ethyl ester on insulin resistance and hypertension in dahl salt-sensitive rats

摘要: We investigated the effect of long-term administration highly purified eicosapentaenoic acid ethyl ester (EPA-E), an n-3 polyunsaturated fatty derived from fish oil, in comparison to lard on development hypertension and insulin resistance Dahl salt-sensitive (Dahl-S) rats fed a high-sucrose diet (HSD), model hypertension. After 16 weeks treatment, glucose infusion rate (GIR) during euglycemic insulin-glucose clamp test significantly increased HSD-EPA-E group compared with HSD-water or -lard control group. The GIR was approximately three times higher versus group, it about 70% calorically deprived low-fat-high-fiber (LF-HFD). In addition, EPA-E suppressed elevation plasma levels after oral loading. These results indicate that prevents Dahl-S HSD. Fatty analysis phospholipids skeletal muscle showed significant increase C18:2, C20:5, C22:5 components and, conversely, decrease C16:0, C20:4, C22:6. present beneficial HSD is likely dependent modification phospholipid membrane. findings suggest might prevent dietary obesity. level uncoupling protein (UCP) brown adipose tissue as However, had no obesity