Antioxidant protection against curative and palliative doses of ionizing irradiation in human blood decreases with aging.
作者： Jelena Kasapović , Vesna Stojiljković , Ljubica Gavrilović , Nataša Popović , Zorka Milićević
DOI: 10.1100/2012/982594
关键词: Superoxide dismutase 、 Glutathione peroxidase 、 Ionizing irradiation 、 Immunology 、 Pharmacology 、 Catalase 、 Reactive oxygen species 、 Detoxification 、 Glutathione 、 Chemistry 、 Antioxidant
摘要: Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and aging process. However, an age-related alteration of antioxidant (AO) system radiation response humans is poorly investigated. The aim this paper was evaluate the irradiation effects activities expression AO blood women during aging. Blood samples were irradiated with curative palliative doses 2 Gy or 9 Gy γ-rays. capacity for detoxification O2•− H2O2 γ-irradiation decreases above 58 years, while shows signs weakening after 45 years age. Due reduction aging, cytotoxic irradiation, mediated by ROS, may significantly increase older subjects, removal excess could reduce them.
hindawi.com
core.ac.uk参考文章(41)
Y Kono, I Fridovich, Superoxide radical inhibits catalase. Journal of Biological Chemistry. ,vol. 257, pp. 5751- 5754 ,(1982) , 10.1016/S0021-9258(19)83842-5
K Arai, S Maguchi, S Fujii, H Ishibashi, K Oikawa, N Taniguchi, Glycation and inactivation of human Cu-Zn-superoxide dismutase. Identification of the in vitro glycated sites. Journal of Biological Chemistry. ,vol. 262, pp. 16969- 16972 ,(1987) , 10.1016/S0021-9258(18)45479-8
Ernest Beutler, Red cell metabolism: A manual of biochemical methods ,(1975)
Wulf Dröge, Oxidative stress and aging. Advances in Experimental Medicine and Biology. ,vol. 543, pp. 191- 200 ,(2003) , 10.1007/978-1-4419-8997-0_14
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Helle Raun Andersen, Jesper B Nielsen, Flemming Nielsen, Philippe Grandjean, Antioxidative enzyme activities in human erythrocytes. Clinical Chemistry. ,vol. 43, pp. 562- 568 ,(1997) , 10.1093/CLINCHEM/43.4.562
Azza H Abou Ghalia, Iman M Fouad, Glutathione and Its Metabolizing Enzymes in Patients with Different Benign and Malignant Diseases Clinical Biochemistry. ,vol. 33, pp. 657- 662 ,(2000) , 10.1016/S0009-9120(00)00181-8
A Tulard, Persistent oxidative stress after ionizing radiation is involved in inherited radiosensitivity Free Radical Biology and Medicine. ,vol. 35, pp. 68- 77 ,(2003) , 10.1016/S0891-5849(03)00243-0
Rajindar S. Sohal, Sanjiv Agarwal, Barbara H. Sohal, Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus) Mechanisms of Ageing and Development. ,vol. 81, pp. 15- 25 ,(1995) , 10.1016/0047-6374(94)01578-A
Alejandro D Bolzán, Martha S Bianchi, Néstor O Bianchi, Superoxide dismutase, catalase and glutathione peroxidase activities in human blood: influence of sex, age and cigarette smoking. Clinical Biochemistry. ,vol. 30, pp. 449- 454 ,(1997) , 10.1016/S0009-9120(97)00047-7