Gene Expression Data from the Moon Jelly, Aurelia, Provide Insights into the Evolution of the Combinatorial Code Controlling Animal Sense Organ Development

摘要: In Bilateria, Pax6, Six, Eya and Dach families of transcription factors underlie the development evolution morphologically phyletically distinct eyes, including compound eyes in Drosophila camera-type vertebrates, indicating that bilaterian evolved under strong influence ancestral developmental gene regulation. However conservation eye genetics deeper Eumetazoa, origin conserved regulatory apparatus controlling remain unclear due to limited comparative data from Cnidaria. Here we show eye-bearing scyphozoan cnidarian Aurelia ectodermal photosensory domain developing medusa sensory structure known as rhopalium expresses sine oculis (so)/six1/2 absent/eya, but not optix/six3/6 or pax (A&B). addition, so eya co-expression encompasses region active cell proliferation, neurogenesis, mechanoreceptor rhopalia. Consistent with role rhopalial development, transcriptome across life cycle stages upregulation eya, optix (A&B), during formation. Moreover, pax6 dach are absent genome, thus required for Aurelia. Our consistent optix, dach, having functions specification Eumetazoa. The lability components Pax genes relative so-eya is a model sense organ involved lineage specific modification combinatorial code specifies animal organs.