Effects of SQ 14.225, an orally active inhibitor of angiotensin-converting enzyme, on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats
作者： D. Kentera , D. Sušić , A. Cvetković , Gordana Djordjević
DOI: 10.1007/BF01907777
关键词: Angiotensin receptor 、 Angiotensin-converting enzyme 、 Pulmonary hypertension 、 Internal medicine 、 Medicine 、 Plasma renin activity 、 Endocrinology 、 Angiotensin II 、 Hypoxic pulmonary vasoconstriction 、 Right ventricular hypertrophy 、 Angiotensin II receptor type 1
摘要: Treatment with SQ 14.225, an inhibitor of the enzyme converting angiotensin I to II and lowering plasma renin activity by dietary salt overload, significantly decreased hypertrophy right ventricle in chronically hypoxic rats. The smaller degree ventricular registered rats suppressed renin-angiotensin system was proportional decrease pulmonary hypertension noted these animals. Lowering suppression reninangiotensin is consistent idea that may be involved eliciting vasoconstriction.
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