Bioinspired structure of bioceramics for bone regeneration in load-bearing sites

摘要: Abstract The major problem with the use of porous bioceramics as bone regeneration grafts is their weak mechanical strength, which has not been overcome to date. Here we described a novel way solve this problem. Beta-tricalcium phosphate (β-TCP) bioinspired structure were designed and prepared cancellous core (porosity: 70–90%) inside dense compact shell 5–10%) outside that mimics characteristics natural bone. They showed excellent properties, compressive strength 10–80 MPa an elastic modulus 180 MPa–1.0 GPa, could be tailored by dense/porous cross-sectional area ratio obeying rule exponential growth. in vitro degradation was faster than but slower counterparts. changes properties ceramics during also investigated. A concept macrostructure design proposed provided simple effective increase for load-bearing applications. It should readily applicable other materials.