Pulmonary Vascular Remodeling by High Oxygen

摘要: As an organ of gas exchange, the lung and its ­vasculature function optimally at level oxygen in air. This chapter reviews effect breathing a higher than normal atmospheric on vasculature lung. The earth’s atmosphere contains 20.99% oxygen, this concentration efficiently sustains life (cell respiration metabolism). Studies have demonstrated toxic effects high tension tissue, mainly response to normobaric hyperoxia, as differences began emerge between organ, or how is administered. Higher partial pressures can be administered reduced total barometric pressure (hypobaric hyperoxia), sea (normobaric greater (hyperbaric hyperoxia). show that injures adult lung’s vasculature, while prolonged exposure hyperbaric hyperoxia induces vasculitis, with endothelial cell proliferation hyalinization walls large small pulmonary arteries. discusses potential mechanisms involved vascular remodeling cycles then air, observations would improve understanding pathobiology changes characterize hypertension, highlights striking degree plasticity bed matching density ambient alveolar tension.