Structure-activity relationships in rodent diaphragm muscle fibers vs. neuromuscular junctions.
作者： Dylan C. Sieck , Wen-Zhi Zhan , Yun-Hua Fang , Leonid G. Ermilov , Gary C. Sieck
DOI: 10.1016/J.RESP.2011.10.015
关键词: Internal medicine 、 Anatomy 、 Endocrinology 、 Muscle fatigue 、 Active muscle 、 Motor unit 、 Neuromuscular transmission 、 Diaphragm (structural system) 、 Diaphragm muscle 、 Biology 、 Rodent 、 Neuromuscular junction
摘要: The diaphragm muscle (DIAm) is a highly active of mixed fiber type composition. We hypothesized that consistent with greater activation history and proportion fatigue-resistant fibers, neuromuscular transmission failure lower in the mouse compared to rat DIAm, junction (NMJ) morphology will match their different functional demands. Minute ventilation duty cycle were higher than rat. fibers was similar mouse; however contribution total DIAm mass mouse. Neuromuscular less mice rats. Motor end-plate area differed across but not where NMJs displayed complexity overall. Thus, differences species susceptibility are reflected relative fatigue resistant mass, type-dependent morphological at NMJ.
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