Structural characterization of Lipoarabinomannans from Mycobacterium tuberculosis and Mycobacterium smegmatis by ESI mass spectrometry.
作者： Christopher J. Petzold , Leslie H. Stanton , Julie A. Leary
DOI: 10.1016/J.JASMS.2005.02.023
关键词: Arabinose 、 Ion trap 、 Mass spectrometry 、 Chemistry 、 Mycobacterium tuberculosis 、 Stereochemistry 、 Mycobacterium 、 Ion cyclotron resonance spectrometry 、 Mass spectrum 、 Chromatography 、 Mycobacterium smegmatis
摘要: Structural aspects of lipoarabinomannans (LAM) from Mycobacterium tuberculosis and smegmatis were investigated by using mild acid hydrolysis in combination with Fourier-transform ion cyclotron resonance (FT-ICR), quadrupole trap mass spectrometry. Exact measurements less than 2.5 ppm error confirmed the presence a series arabinose oligomers (Aran; n=2–7) as major components observed following both M. LAM. However, spectrum resulting LAM extract also revealed highly-abundant distribution ions that exact identified mannose-linked species, AranManm+Na+ (n=1–6; m=1–3). The mannose caps linked to species mono-, di-, trimannose units, ratio was determined be 1.00:9.00:1.15, respectively, different previous reports. Analysis linkage lithiated trimer standards accomplished MS3 experiments information generated used identify linkages trimers spectra predominantly α(1 → 5), 5).
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T M Kaufman, L S Schlesinger, S R Hull, Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages. Journal of Immunology. ,vol. 152, pp. 4070- 4079 ,(1994)
A. Venisse, J.M. Berjeaud, P. Chaurand, M. Gilleron, G. Puzo, Structural features of lipoarabinomannan from Mycobacterium bovis BCG. Determination of molecular mass by laser desorption mass spectrometry. Journal of Biological Chemistry. ,vol. 268, pp. 12401- 12411 ,(1993) , 10.1016/S0021-9258(18)31404-2
D Chatterjee, K Lowell, B Rivoire, M.R. McNeil, P.J. Brennan, Lipoarabinomannan of Mycobacterium tuberculosis. Capping with mannosyl residues in some strains. Journal of Biological Chemistry. ,vol. 267, pp. 6234- 6239 ,(1992) , 10.1016/S0021-9258(18)42686-5
J Chan, X D Fan, S W Hunter, P J Brennan, B R Bloom, LIPOARABINOMANNAN, A POSSIBLE VIRULENCE FACTOR INVOLVED IN PERSISTENCE OF MYCOBACTERIUM TUBERCULOSIS WITHIN MACROPHAGES Infection and Immunity. ,vol. 59, pp. 1755- 1761 ,(1991) , 10.1128/IAI.59.5.1755-1761.1991
Jérôme Nigou, Martine Gilleron, Germain Puzo, Lipoarabinomannans: from structure to biosynthesis. Biochimie. ,vol. 85, pp. 153- 166 ,(2003) , 10.1016/S0300-9084(03)00048-8
Barry R Bloom, Christopher JL Murray, None, Tuberculosis: commentary on a reemergent killer. Science. ,vol. 257, pp. 1055- 1064 ,(1992) , 10.1126/SCIENCE.257.5073.1055
Kay-Hooi Khoo, Anne Dell, Howard R. Morris, Patrick J. Brennan, Delphi Chatterjee, Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium Journal of Biological Chemistry. ,vol. 270, pp. 12380- 12389 ,(1995) , 10.1074/JBC.270.21.12380
Zhongrui Zhou, Sherri Ogden, Julie A. Leary, Linkage position determination in oligosaccharides: mass spectrometry (MS/MS) study of lithium-cationized carbohydrates Journal of Organic Chemistry. ,vol. 55, pp. 5444- 5446 ,(1990) , 10.1021/JO00307A011
Glenn Smith, Steven F. Pedersen, Julie A. Leary, Stereoselective β-Hydrogen Elimination from Nickel(II)−N-Glycoside Complexes Journal of Organic Chemistry. ,vol. 62, pp. 2152- 2154 ,(1997) , 10.1021/JO9622789
Gretchen E. Hofmeister, Zhongrui Zhou, Julie A. Leary, Linkage position determination in lithium-cationized disaccharides: tandem mass spectrometry and semiempirical calculations Journal of the American Chemical Society. ,vol. 113, pp. 5964- 5970 ,(1991) , 10.1021/JA00016A007