Prognostic factors in laryngeal carcinoma experience in 296 male patients

作者: Roberto Pradier , Abel González , Elena Matos , Dora Loria , Roque Adan

DOI: 10.1002/1097-0142(19930415)71:8<2472::AID-CNCR2820710808>3.0.CO;2-Y

关键词: Cause of deathHead and neck cancerPrimary tumorEpidermoid carcinomaRisk factorCancerOncologyPrognostic variableInternal medicineSurgeryUnivariate analysisMedicine

摘要: Background. Laryngeal cancer is the primary cause of death among patients with head and neck in Argentina. Different prognostic factors have been incidentally dealt a number articles, but there are few studies variables, such as age, tobacco, alcohol, using multifactorial analysis. Methods. Between 1969–1987, 296 male epidermoid carcinoma larynx treated at Institute Oncology “Angel H. Roffo” were studied regarding survival. The effect histologic grade, extent tumor, cord mobility on survival assessed by means Cox proportional-hazards model. Results. univariate analysis showed that tumor extent, nodal involvement, stage, alcohol intake, previous tracheostomy, statistically significant predictors Multivariate disclosed only variables regard to survivorship. With these hazard index was calculated for each patient, four risk groups formed. Five-year rates follows: Group A, 79%; B, 69%; C, 47%; D, 14% (A versus P < 0.005; A 0.005). Conclusions. This study confirmed impact involvement also importance fixation drinking

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