Effect of endothelin-1 on the uterine vasculature of the pregnant and estrogen-treated nonpregnant sheep.
作者： Daseng Yang , Kenneth E. Clark
DOI: 10.1016/0002-9378(92)91755-Y
关键词: Hemodynamics 、 Uterine artery 、 Internal medicine 、 Medicine 、 Endocrinology 、 Vascular resistance 、 Uterus 、 Endothelin 1 、 Vasoconstriction 、 Phenylephrine 、 Norepinephrine (medication)
摘要: Abstract OBJECTIVE: This study was designed to evaluate the uterine vascular responses endothelin-1 in pregnant and estrogen-treated nonpregnant sheep. STUDY DESIGN: Seven five oophorectomized ewes received local artery infusions of endothelin-1, norepinephrine, phenylephrine. Arterial blood pressure, heart rate, flow were recorded. RESULTS: Endothelin-1 (0.01 3.0 µg/min), norepinephrine (0.1 3 phenylephrine 10 µg) produced significant dose-related decreases increases resistance. On a nanomoles infused per minute basis, much more potent than as vasoconstrictor both The similar ewes, whereas response blunted pregnancy. CONCLUSION: is an extremely but responsiveness decreased (AM J OBSTET GYNECOL 1992;167:1642-50.)
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