Ischemia–Reperfusion Injury Following Superior Mesenteric Artery Occlusion and Strangulation Obstruction
作者： Adem Akcakaya , Orhan Alimoglu , Mustafa Sahin , Semra Dogru Abbasoglu
关键词: Surgery 、 Vascular disease 、 SMA* 、 Small intestine 、 Anesthesia 、 Reperfusion injury 、 Stenosis 、 Medicine 、 Occlusion 、 Ischemia 、 Superior mesenteric artery
摘要: Background. Intestinal ischemia–reperfusion injury (IRI) is a serious and common clinical entity resulting in severe tissue injury. This study was designed to compare IRI superior mesenteric artery (SMA) occlusion strangulation obstruction (SO). Materials Methods. Thirty Wistar-Albino rats were assigned randomly three groups. In the control group, sham operation performed. SMA vascular clamp placed across occlude arterial circulation. SO 15-cm segment of small intestine looped prevent venous Sixty minutes ischemia followed by 60 min reperfusion. Following reperfusion, biopsies taken assess morphologic damage, levels malonyldialdehyde (MDA) as an index lipid peroxidation reflecting oxygen free radicals (OFR) determined, serum biochemical analyses performed. Results. The MDA significantly higher group than (P < 0.05). Biochemical parameters groups those there significant difference between models, except for ALP levels. Histopathologically, transmural intestinal damage present seven cases six group. Conclusions. Despite no two terms OFR-induced group.
elsevier.com
sci-hub.se 参考文章(26)
Barbara J. Zimmerman, Matthew B. Grisham, D. Neil Granger, Mechanisms of oxidant-mediated microvascular injury following reperfusion of the ischemic intestine. Basic life sciences. ,vol. 49, pp. 881- 886 ,(1988) , 10.1007/978-1-4684-5568-7_143
Marchuk S, Finley Rj, Moffat D, Taylor Bm, DeRose G, Pliagus G, Jamieson Wg, Stafford L, Duff J, Sibbald W, Effect of antibiotic and fluid resuscitation upon survival time in experimental intestinal ischemia. Surgery gynecology & obstetrics. ,vol. 167, pp. 103- 108 ,(1988)
D A Parks, M E Höllwarth, D N Granger, Ischemia-reperfusion injury: role of oxygen-derived free radicals. Acta Physiologica Scandinavica. ,vol. 548, pp. 47- 63 ,(1986)
U Haglund, G B Bulkley, P O Park, K Fält, The sequence of development of intestinal tissue injury after strangulation ischemia and reperfusion. Surgery. ,vol. 107, pp. 574- 580 ,(1990)
F J Scholz, Ischemic bowel disease Radiologic Clinics of North America. ,vol. 31, pp. 1197- 1218 ,(1993)
Dale A. Parks, Gregory B. Bulkley, D.Neil Granger, Stanley R. Hamilton, Joe M. McCord, Ischemic injury in the cat small intestine: Role of superoxide radicals Gastroenterology. ,vol. 82, pp. 9- 15 ,(1982) , 10.1016/0016-5085(82)90115-9
D.Neil Granger, Gianfranco Rutili, Joe M. McCord, Superoxide radicals in feline intestinal ischemia Gastroenterology. ,vol. 81, pp. 22- 29 ,(1981) , 10.1016/0016-5085(81)90648-X
Ulf A. Nilsson, Michael H. Schoenberg, Anders Åneman, Bertram Poch, Sunita Magadum, Hans G. Beger, Ove Lundgren, Free radicals and pathogenesis during ischemia and reperfusion of the cat small intestine Gastroenterology. ,vol. 106, pp. 629- 636 ,(1994) , 10.1016/0016-5085(94)90695-5
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
M.H. Schoenberg, H.G. Beger, Oxygen radicals in intestinal ischemia and reperfusion Chemico-Biological Interactions. ,vol. 76, pp. 141- 161 ,(1990) , 10.1016/0009-2797(90)90085-2