Evaluation of antimicrobial use in a pediatric intensive care unit

摘要: A pediatric intensivist in the University of Iowa Hospitals and Clinic’s (UIHC) Pediatric Intensive Care Unit (PICU) was concerned about antimicrobial use unit. However, no one had quantified UIHC’s PICU or described patterns this To address intensivist’s concern, principal investigator (PI) conducted a retrospective study to determine percentage patients who received treatments, indications for use, identify agents used most frequently On basis our data, we hypothesized that empiric particularly duration therapy, could be decreased. We implemented six-month intervention during which asked intensivists complete an assessment form (AA) document their rationale starting treatments. postulated documentation process might remind physicians review therapies, especially when microbiologic data became available. In addition, utilized AA factors considered deciding prescribe Data from forms suggested often elevated C-reactive protein, white blood cell counts, temperatures start therapy. three nested periods showed median targeted treatments decreased remained stable postintervention period. The PI estimated 193 days therapy 59 respectively, may have been saved by durations Time series analysis assessing trend piperacillin-tazobactam, cefepime, ceftriaxone (measured mg/wk) did not reveal significant change over time.