Plasmodium falciparum gametocyte-infected erythrocytes do not adhere to human primary erythroblasts.

摘要: Plasmodium falciparum gametocytes, the sexual stages responsible for malaria parasite transmission, develop in human bone marrow parenchyma proximity to erythroblastic islands. Yet, mechanisms underlying gametocytes interactions with these islands are unknown. Here, we have investigated whether gametocyte-infected erythrocytes (GIE) adhere erythroid precursors, and a putative adhesion may be mediated by mechanism similar of infected P. asexual uninfected erythrocytes. Cell-cell assays primary erythroblasts or cell lines revealed that immature GIE do not specifically precursors. To determine dependent on binding STEVOR proteins Glycophorin C surface cells, used clonal transgenic parasites overexpress specific known bind stages. Our results indicate overexpressing erythroblasts, agreement our observation adhesive domain is exposed at GIE.