Dual Effects of Weight and Weight Gain on Breast Cancer Risk
作者： Zhiping Huang , Susan E. Hankinson , Graham A. Colditz , Meir J. Stampfer , David J. Hunter
DOI: 10.1001/JAMA.1997.03550170037029
关键词: Risk factor 、 Breast cancer 、 Weight change 、 Body mass index 、 Obstetrics 、 Cohort 、 Gynecology 、 Prospective cohort study 、 Menopause 、 Medicine 、 Cohort study
摘要: Context. —Breast cancer is a major cause of mortality among women. It important to identify modifiable risk factors for this disease. Objective. —To examine body mass index (BMI) at the age 18 years and midlife adult weight change in relation breast incidence mortality. Design. —Cohort study. Setting. —A cohort 95256 US female nurses aged 30 55 who were followed up 16 years. Main Outcome Meausure. —Incident fatal cancer. Results. —During 1 203498 person-years, 2517 incident cancers (60% postmenopausal) documented. Higher current BMI was associated with lower before menopause minimally after menopause. However, stronger positive relationship seen postmenopausal women never used hormone replacement (relative risk=1.59 >31 kg/m2vs ≤20 kg/m2; 95% confidence interval, 1.09-2.32;Pfor trend Conclusions. —Avoiding gain may contribute importantly prevention menopause, particularly do not use hormones.
ama-assn.org
sci-hub.se 参考文章(25)
Debora Barnes-Josiah, John D. Potter, Thomas A. Sellers, John H. Himes, Early body size and subsequent weight again as predictors of breast cancer incidence (Iowa, United States) Cancer Causes and Control. ,vol. 6, pp. 112- 118 ,(1995) , 10.1007/BF00052771
Harry W. Daniell, Edward Tam, Albert Filice, Larger axillary metastases in obese women and smokers with breast cancer--an influence by host factors on early tumor behavior. Breast Cancer Research and Treatment. ,vol. 25, pp. 193- 201 ,(1993) , 10.1007/BF00689833
Steinar Tretli, Height and weight in relation to breast cancer morbidity and mortality. A prospective study of 570,000 women in Norway. International Journal of Cancer. ,vol. 44, pp. 23- 30 ,(1989) , 10.1002/IJC.2910440105
Giske Ursin, Matthew P. Longnecker, Robert W. Haik, Sander Greenland, A meta-analysis of body mass index and risk of premenopausal breast cancer. Epidemiology. ,vol. 6, pp. 137- 141 ,(1995) , 10.1097/00001648-199503000-00009
Loren Lipworth, Hans-Olov Adami, Dimitrios Trichopoulos, Kjell Cartström, Christos Mantzoros, Serum steroid hormone levels, sex hormone-binding globulin, and body mass index in the etiology of postmenopausal breast cancer. Epidemiology. ,vol. 7, pp. 96- 100 ,(1996) , 10.1097/00001648-199601000-00017
S Tretli, T Haldorsen, L Ottestad, The effect of pre-morbid height and weight on the survival of breast cancer patients. British Journal of Cancer. ,vol. 62, pp. 299- 303 ,(1990) , 10.1038/BJC.1990.282
Ruby T. Senie, Obesity at Diagnosis of Breast Carcinoma Influences Duration of Disease-free Survival Annals of Internal Medicine. ,vol. 116, pp. 26- 32 ,(1992) , 10.7326/0003-4819-116-1-26
SA Törnberg, JM Carstensen, Relationship between Quetelet's index and cancer of breast and female genital tract in 47,000 women followed for 25 years. British Journal of Cancer. ,vol. 69, pp. 358- 361 ,(1994) , 10.1038/BJC.1994.65
Raymond W. Jurgens, Laurence J. Downey, William D. Abernethy, Neal R. Cutler, Julie Conrad, A comparison of circulating hormone levels in postmenopausal women receiving hormone replacement therapy American Journal of Obstetrics and Gynecology. ,vol. 167, pp. 459- 460 ,(1992) , 10.1016/S0002-9378(11)91429-X
Polly A. Newcomb, Ronald Klein, Barbara E. K. Klein, Steven Haffner, Julie Mares-Perlman, Karen J. Cruickshanks, Pamela M. Marcus, Association of dietary and life-style factors with sex hormones in postmenopausal women. Epidemiology. ,vol. 6, pp. 318- 321 ,(1995) , 10.1097/00001648-199505000-00022