Afferent influences on striatal development in organotypic cocultures.
作者： Abigail Snyder‐Keller , Kuei Y Tseng , Gregory D Lyng , David J Graber , Patricio O'Donnell
DOI: 10.1002/SYN.20518
关键词: Substantia nigra 、 Neuroscience 、 Dopamine 、 Biology 、 Neuropil 、 Striatum 、 Cerebral cortex 、 Cortex (anatomy) 、 Medium spiny neuron 、 Midbrain
摘要: Organotypic cocultures of striatum, cortex, and ventral mesencephalon were used to study the anatomical physiological development striatal neurons in presence or absence cortical nigral (SN/VTA) inputs. Striatum cortex dissected from prenatal (E18-E22) early postnatal (P0-P2) rats, SN/VTA was E14-15 fetuses; pieces maintained up 3 weeks static slice culture. Triple containing exhibited rapid robust dopamine (DA) innervation striatum a patchy pattern, homogeneous distribution within piece, regardless orientations three pieces. DA fibers piece overlapped patch neurons, marked by DARPP-32 immunoreactivity, cultures prepared all age but most analogous that seen vivo observed with use late (E20-E22) striatum. The patch/matrix organization nigrostriatal afferents. In addition, more complete transition E18/19 innervation. Electrophysiological recording demonstrated both spontaneous cortically evoked activity medium spiny neurons; this greatly influenced These findings demonstrate importance afferent maturation organotypic cultures.
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