Porous Polycaprolactone-Polystyrene Semi-interpenetrating Polymer Networks Synthesized within High Internal Phase Emulsions

摘要: PolyHIPE are highly porous, open-pore, cross-linked polymers synthesized within high internal phase emulsions (HIPE). Biodegradable polycaprolactone (PCL) oligomers were incorporated into polyHIPE using two approaches. The first approach involved copolymerization with a vinyl-terminated PCL (PCL-VL). This yielded typical structure voids on the order of tens microns. covalent bonds formed by PCL-VL prevented its removal during emulsifier extraction. second formation semi-interpenetrating polymer networks (semi-IPN) diol (PCL-OL). relatively hydrophilic PCL-OL destabilized HIPE and produced hundreds microns, size more appropriate for tissue engineering applications. PCL-OL, which is mobile than covalently bound PCL-VL, underwent extensive separation. In addition, significant amount was removed Cells successfully attached to surface semi-IPN polyHIPE, forming monolayer. Eventually, spontaneous differentiation cells myotubes observed.