Use Dependence and Reverse Use Dependence of Antiarrhythmic Agents: Pro- and Antiarrhythmic Actions

摘要: The normal heart beat starts at regular intervals (600–1000 ms) in the SA node, then propagates through atria to enter AV where conduction is slow. With some delay it enters His-Purkinje system which quickly activates ventricular myocardium. When activation of deviates from this sequence an arrhythmia results. most serious arrhythmias are those pumping function jeopardized like fibrillation and tachycardia. In fibrillation, there exists no synchronization between cells so that blood stops, while tachycardia contracts frequently before has properly filled. As a result cardiac output very low. Because seriousness these two arrhythmias, I concentrate on electropharmacology agents interfere with tachycardias fibrillation.