Étude de l'association hépatite auto-immune et antiphospholipides
作者： S. Branger , N. Schleinitz , V. Veit , C. Martaresche , M. Bourlière
DOI: 10.1016/J.REVMED.2006.12.005
关键词: Gynecology 、 Immunopathology 、 Medicine
摘要: Resume Propos La presence d'anticorps antiphospholipides dans les hepatites auto-immunes a ete peu etudiee. Nous avons etabli la prevalence de ces auto-anticorps une serie d'hepatites et recherche correlation avec des manifestations cliniques, biologiques histologiques. Methode Les anticorps ont recherches chez 24 malades definies. Une etude cas temoin l'analyse litterature realisees. Resultats est 70,8 % (17/24). Quatre syndromes sont identifies (28,6 %). retrouves par ordre frequence sont : l'IgG ACL (52,9 %), l'IgM APE l'ACC (43,7 %), Aβ2GP1 (41,2 %). L'hypergammaglobulinemie n'est pas correlee ou l'isotype l'antiphospholipide. L'âge moyen patients 39,9 ans (± 14,1) le sex-ratio H/F 4/13. Sept sur 17 un diagnostic lupus erythemateux dissemine groupe antiphospholipide positif. caracteristiques clinicobiologiques l'evolution maladie hepatique ne semblent liees l'anticorps. Conclusion confirmons elevee auto-immunes. Notre permet retrouver histologiques particulieres aux APL. L'analyse longitudinale plus grandes cohortes devrait permettre d'eclaircir cette association eventuelles implications therapeutiques.
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