Comparative and environmental genotoxicity of antimony and arsenic.

作者: Gebel T , Christensen S , Dunkelberg H

DOI:

关键词: AntimonyCarcinogenSister chromatid exchangeAntagonismContaminationToxicologySoil contaminationGenotoxicityEnvironmental chemistryArsenicChemistry

摘要: Antimony and arsenic compounds are known to have a genotoxic potential. Soil contamination with these elements can be due the presence of natural ore sources fahlore (gray copper). As result, human animal populations may highly exposed. The sister chromatid exchange (SCE) test is an adequate tool for sensitive detection antimony genotoxicity. We used this assay investigate coergism two in vitro gain data assessment putative risk from coexposure. combinative effect SCE appeared subadditive. Additionally, served determine potential extracts contaminated soil samples gained under mildly acidic conditions. genotoxicity observed was very low because predominated pentavalent, non-genotoxic state, but, partial antagonism experiments could additional explanation

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