Apoptosis in Bone Cells

摘要: Apoptosis is an important regulatory process that, in combination with cell division, determines not only numbers, but also the shape and volume of individual organs (Kerr et al. 1972; Wyllie 1980). It critical during embryonic development for elimination superfluous cells, such as connective tissue between developing fingers (a bone morphogenetic protein (BMP)-dependent process; Zou Niswander 1996; Yokouchi 1996), ensuring that folding rotation primitive tissues occur at precise times. High mitotic low apoptotic rates ensure rapid growth highly malignant tumors (Mooney 1995), while induction massive apoptosis a major mechanism action most chemotherapeutic agents (Lowe 1993) irradiation therapy (Lee Bernstein to reduce tumor volume. Large-scale breast cells follows cessation lactation leads associated reduction size, shrinkage prostatic after orchidectomy occurs by similar (Reed 1994). Because hormonally sensitive tissue, it possible could be determinant and, prostate, amount present likely regulated activity hormones factors.