Mechanisms by which Candida albicans induces endothelial cell prostaglandin synthesis.

摘要: One strategy for improving resistance to opportunistic pathogens is determine host cellular responses during the invasion process and upregulate those that are relevant defense mechanisms. Within this context, we have shown previously of endothelial cells by Candida albicans in vitro causes increased production prostaglandins. As a prerequisite modulating cell prostaglandin production, now characterize mechanisms through which occurs. Endothelial C. appeared stimulate conversion arachidonic acid into prostaglandins upregulating synthesis cyclooxygenase increasing activity phospholipase. The enhanced activities these two enzymes were independent calphostin C-sensitive protein kinase C resulted extracellular secretion I2 (PGI2), PGF2 alpha, PGE2. had no effect on amount injury induced albicans. role likely related modulation leukocyte response at candida-leukocyte-endothelial interface.