The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning.
作者： G.N. Carmona , T. Nishimura , C.W. Schindler , L.V. Panlilio , A.L. Notkins
DOI: 10.1016/J.NEUROSCIENCE.2014.03.023
关键词: Hippocampus (mythology) 、 Dopamine 、 Secretion 、 Striatum 、 CREB 、 Biology 、 Transporter 、 Ca2+/calmodulin-dependent protein kinase 、 Phosphorylation 、 Internal medicine 、 Endocrinology
摘要: The islet-antigens IA-2 and IA-2β are major autoantigens in type-1 diabetes transmembrane proteins dense core vesicles (DCV). Recently we showed that deletion of both alters the secretion hormones neurotransmitters impairs behavior learning. present study was designed to evaluate contribution learning each these genes by using single knockout (SKO) double (DKO) mice an active avoidance test. After 5 days training, wild-type (WT) 60-70% responses, whereas DKO only 10-15% responses. degree responses SKO similar mice, but contrast, behaved like WT showing Molecular studies revealed a marked decrease phosphorylation cAMP response element-binding protein (CREB) Ca(2+)/calmodulin-dependent kinase II (CAMKII) striatum hippocampus not mice. To role CREB CAMKII GBR-12909, which selectively blocks dopamine uptake transporter increases phosphorylation, administered. GBR-12909 restored increased near normal levels found We conclude absence DCV IA-2, is impaired.
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