Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125.

摘要: OC125, a murine monoclonal antibody, recognizes an antigenic determinant (CA125) that is associated with greater than 80% of epithelial ovarian neoplasms serous, endometrioid, clear cell, and undifferentiated types. In the present report, sensitive biotin-avidin immunoperoxidase technique was used to determine reactivity OC125 normal adult fetal tissues, as well nonovarian origin. antibody reacted amnion derivatives coelomic epithelium, i.e., mullerian epithelium lining cells peritoneum, pleura, pericardium. Among fallopian tubes, endometrium, endocervix. The CA125 also detected on mesothelial in pericardium, particularly areas inflammation adhesion. Curiously, surface ovaries, thought be derived from did not express determinant, except inclusion cysts, metaplasia, papillary excrescences. Of neoplastic tissues origin, consistently only adenocarcinomas endocervix, tube, mesotheliomas. Only seven 64 nongynecological tumors tested OC125. Thus, detects differentiation antigen shared by its fetus adult. Apparently, this disappears early course formation reexpressed certain reactive lesions, process could termed "molecular metaplasia."